Paxlovid Drug Interactions List PDF

Paxlovid Drug Interactions List PDF Download

Paxlovid Drug Interactions List PDF Download for free using the direct download link given at the bottom of this article.

Paxlovid Drug Interactions List PDF Details
Paxlovid Drug Interactions List
PDF Name Paxlovid Drug Interactions List PDF
No. of Pages 35
PDF Size 1.67 MB
Language English
CategoryEnglish
Source www.fda.gov
Download LinkAvailable ✔
Downloads17

Paxlovid Drug Interactions List

Hey folks, here we are providing Paxlovid Drug Interactions List PDF to all of you. Paxlovid Drug Interactions are very important for those who are associating with it or planning to use it. It is very necessary to know about all the interactions of medicine before using it.

As you have already seen in the past during the covid 19 pandemic that there were so many cases of death due to the fake vaccine. Therefore, after facing these types of terrific problems during that time government became more aware of the quality check of these supplies.

Paxlovid Drug Interactions List PDF

Box 1. Commonly Prescribed Outpatient Medications Not Expected to Have Clinically Relevant Interactions With Ritonavir-Boosted Nirmatrelvir (Paxlovid)

Medications Without Clinically Relevant Interactions

These commonly prescribed medications may be coadministered without dose adjustment and without increased monitoring. This list is not inclusive of all noninteracting medications within each drug category.
1. Acid reducing agents
  • Famotidine
  • Omeprazole
  • Pantoprazole
2. Allergy medications
  • Cetirizine
  • Diphenhydramine
  • Loratadine
3. Anti-infective agents
  • Azithromycin
  • Hydroxychloroquine
4. Cardiovascular agents
  • Aspirin
  • Atenolol
  • Carvedilol
  • Furosemide
  • Hydrochlorothiazide
  • Irbesartan
  • Isosorbide Dinitrate
  • Lisinopril
  • Losartan
  • Metoprolol
  • Prasugrel
5. Diabetes medications
  • Empagliflozin
  • Insulin
  • Metformin
  • Pioglitazone
6. Immunosuppressants
  • Methotrexate
  • Mycophenolate
  • Prednisone
7. Lipid-modifying agents
  • Ezetimibe
  • Pitavastatin
  • Pravastatin
8. Neuropsychiatric agents
  • Amitriptyline
  • Bupropion
  • Citalopram
  • Duloxetine
  • Escitalopram
  • Fluoxetine
  • Gabapentin
  • Lorazepam
  • Nortriptyline
  • Olanzapine
  • Paroxetine
  • Sertraline
  • Venlafaxine
9. Pain medications
  • Acetaminophen
  • Aspirin
  • Codeine
  • Ibuprofen
  • Naproxen
10. Respiratory medications
  • Corticosteroids (inhaled)
  • Formoterol
  • Montelukast
11. Miscellaneous
  • Allopurinol
  • Contraceptives (oral)b
  • Donepezil
  • Enoxaparin
  • Finasteride
  • Levothyroxine
  • Ondansetron

Box 2. Outpatient Medications That Have Clinically Relevant Drug-Drug Interactions With Ritonavir-Boosted Nirmatrelvir (Paxlovid)

Prescribe Alternative COVID-19 Therapy
For these medications, management strategies are not possible or feasible, or the risks outweigh the potential benefits.
Anticonvulsants

  • Carbamazepine
  • Phenobarbital
  • Phenytoin
  • Primidone

Anti-infective agents

  • Glecaprevir/pibrentasvir
  • Rifampin
  • Rifapentine

Immunosuppressants

  • Voclosporin
Cardiovascular agents

  • Amiodarone
  • Clopidogrela,b
  • Disopyramide
  • Dofetilide
  • Dronedarone
  • Eplerenone
  • Flecainide
  • Ivabradine
  • Propafenone
  • Quinidine

Neuropsychiatric agents

  • Clozapine
  • Lumateperone
  • Lurasidone
  • Midazolam (oral)
  • Pimozide
Pain medications

  • Meperidine (pethidine)

Pulmonary hypertension medications

  • Sildenafil
  • Tadalafil
  • Vardenafil

Miscellaneous

  • Bosentan
  • Certain chemotherapeutic agentsc
  • Ergot derivatives
  • Lumacaftor/ivacaftor
  • St. John’s wort
  • Tolvaptan
Temporarily Withhold Concomitant Medication, If Clinically Appropriate
Withhold these medications during ritonavir-boosted nirmatrelvir treatment and for at least 2–3 days after treatment completion. They may need to be withheld for longer if the patient is elderly or the medication has a long half-life. If withholding is not clinically appropriate, use an alternative concomitant medication or COVID-19 therapy.
Anticoagulants

  • Rivaroxaband

Anti-infective agents

  • Erythromycin

BPH medications

  • Alfuzosin
  • Silodosin

Cardiovascular agents

  • Aliskiren
  • Ranolazine
  • Ticagrelorb
  • Vorapaxar

Immunosuppressantsf

  • Everolimus
  • Sirolimus
  • Tacrolimus
Lipid-modifying agents

  • Atorvastatine
  • Lomitapide
  • Lovastatine
  • Rosuvastatine
  • Simvastatine

Migraine medications

  • Eletriptan
  • Rimegepant
  • Ubrogepant

Neuropsychiatric agents

  • Clonazepamg
  • Clorazepateg
  • Diazepamg
  • Estazolamg
  • Flurazepamg
  • Suvorexant
  • Triazolamg
Erectile dysfunction medications

  • Avanafil

Respiratory medications

  • Salmeterol

Miscellaneous

  • Certain chemotherapeutic agentsc
  • Colchicineh
  • Finerenone
  • Flibanserin
  • Naloxegol
Adjust Concomitant Medication Dose and Monitor for Adverse Effects
Consult the Liverpool COVID-19 Drug Interactions website or the Ontario COVID-19 Science Advisory Table for specific dosing recommendations.i If the dose of the concomitant medication cannot be adjusted, withhold the medication (if clinically appropriate) or use an alternative concomitant medication or COVID-19 therapy.
Anticoagulants

  • Apixaban
  • Dabigatran
  • Edoxaban

Anti-infective agents

  • Clarithromycin
  • Itraconazole
  • Ketoconazole
  • Maraviroc
  • Rifabutin

BPH medications

  • Tamsulosin

Cardiovascular agents

  • Cilostazol
  • Digoxin
  • Mexiletine

Diabetes medications

  • Saxagliptin
Erectile dysfunction medications

  • Sildenafil
  • Tadalafil
  • Vardenafil

Immunosuppressantsf

  • Cyclosporine

Neuropsychiatric agents

  • Alprazolamg
  • Aripiprazole
  • Brexpiprazole
  • Buspirone
  • Cariprazine
  • Chlordiazepoxideg
  • Clobazamg
  • Iloperidone
  • Pimavanserin
  • Quetiapine
  • Trazodone
Pain medications

  • Fentanyl
  • Hydrocodone
  • Oxycodone

Pulmonary hypertension medications

  • Riociguat

Miscellaneous

  • Certain chemotherapeutic agentsc
  • Darifenacin
  • Elexacaftor/tezacaftor/
    ivacaftor
  • Eluxadoline
  • Ivacaftor
  • Tezacaftor/ivacaftor
Continue Concomitant Medication and Monitor for Adverse Effects
Pre-emptive dose adjustment is not required but may be considered. Educate patients on potential adverse effects. Consult the Liverpool COVID-19 Drug Interactions website or the Ontario COVID-19 Science Advisory Table for monitoring guidance and dose adjustment information if needed.i
Anticoagulants

  • Warfarin

Anti-infective agents

  • Cobicistat or ritonavir-boosted antiretrovirals
  • Isavuconazole
  • Posaconazole
  • Voriconazole

BPH medications

  • Doxazosin
  • Terazosin

Diabetes medications

  • Glyburide
Cardiovascular agents

  • Amlodipine
  • Diltiazem
  • Felodipine
  • Nifedipine
  • Sacubitril
  • Valsartan
  • Verapamil

Neuropsychiatric agents

  • Haloperidol
  • Hydroxyzine
  • Mirtazapine
  • Risperidone
  • Ziprasidone
  • Zolpidem

You can download Paxlovid Drug Interactions List PDF by clicking on the following download button.


Paxlovid Drug Interactions List PDF Download Link